A large cannabis crop of 854 mature plants has been located near Coonalpyn.
It comes after police uncovered 486 mature cannabis plants growing in scrub in near the town on Monday, March 24.
As part of Operation Argon, the SA Police Serious and Organised Crime Branch began investigation "the syndicated large commercial cultivation and trafficking of cannabis" in September 2019, a police statement said.
It was through this operation that detectives arrested five men from Adelaide's suburbs after the first crop find near Coonalpyn.
The men faced Adelaide Magistrates Court on Wednesday, March 25.
Further searches undertaken during the week led detectives to a second crop near Coonalpyn, which was home to 854 mature cannabis plants.
This brought the total of plants seized to 1347.
Police involved in Operation Argon continue to investigate the second crop.
Serious and Organised Crime Branch acting Detective Chief Inspector Jon Halliday said it was "another significant seizure".
"While some criminals might think they are reducing their risk of apprehension by operating in remote areas, Operation Argon clearly demonstrates this not to be the case," he said.
Anyone who trafficks illicit drugs can be fined up to $500,000 fine or face life in jail, and can also lose assets such as houses and cars.
Anyone with information about drug trafficking, cultivation or manufacture can contact Crime Stoppers on 1800 333 000 or at www.crimestopperssa.com.au - you can remain anonymous.